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Adams County is a county located in the U.S. state of Mississippi. As of 2016, the population was 31,248. Its name is in honor of the second President of the United States, John Adams. The county seat is Natchez.
Adams County was created on April 2, 1799, from part of Pickering Territorial County. It was the first county to be organized in the Mississippi Territory, eighteen years before Mississippi became a state. Its namesake is President John Adams.