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DeSoto County is a county located in the U.S. state of Mississippi. DeSoto County is part of the Metropolitan Memphis Statistical Area. Its county seat is Hernando. As of 2016, the population was 175,611.
DeSoto County is named for Spanish explorer Hernando de Soto, the discoverer of the Mississippi River. The county seat, Hernando, is also named in his honor. De Soto allegedly died in that area in May 1542, although some believe that he died near Lake Village, Arkansas.